Disclaimer: Limited data exist on Low-5 (low-dose 5-MeO-DMT) and its effects on humans. Anyone who uses Low-5 or any psychedelics does so at their own risk. The authors do not recommend using any substance without close medical supervision and, as such, are not responsible for any consequences of the use of psychedelics or substances by readers of this protocol or otherwise. Always adhere to local laws.
Welcome to the Low-5 Guide
Low‑5 (low‑dose 5‑MeO‑DMT) is quietly gaining presence in therapeutic settings—but remains poorly understood outside a small circle of practitioners and researchers. This guide brings together 100 key terms, concepts, risks, and techniques shaping the emerging Low‑5 landscape.
Too many people have shaped this guide to name—through their writing, field notes, workshops, feedback, and community presence. Much of what follows draws from reports of practitioner experience, retrospective data, and observational findings. We’re especially grateful to the Toronto‑based volunteers who helped bring it together—and to our paying subscribers, whose support helps make this work possible.
To suggest edits or additions, email us at team@patternproject.ca.
Thank you for reading.
TABLE OF CONTENTS
1. Chemistry & Molecular Identity
2. Neuropharmacology & Brain Science
3. Hardware and Formulations
4. Routes of Low-5 Administration
5. Dosing Fundamentals
6. Low-5 Dosing Terms
7. Safety, Risk & Harm Reduction
8. Side Effects and Adverse Reactions
9. Low-5 Ascent, Peak, Descent, Tail, Baseline
10. Low-5 Session Dynamics
11. High-5 Session Dynamics
12. Therapeutic Frameworks
13. Therapeutic Terms and Techniques
14. Integration and Aftercare
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